Active skincare ingredients
  • Acetyl Hexapeptide-8
  • Shaanxi Huatai Bio-Fine Chemicals Co., Ltd

Acetyl Hexapeptide-8

The Topical Neuro-Peptide Specialist for Smoothing Dynamic Wrinkles

Acetyl Hexapeptide-8, widely known as the “topical botox,” is a high-performance cosmetic grade neuro-peptide. It is specifically designed to target the biochemical mechanisms of wrinkle formation by modulating neurotransmitter release, effectively smoothing fine lines on the forehead and around the eyes.

CAS No.

616204-22-9

Source

High-Purity Peptide Synthesis

Appearance Color

White Powder or Colorless Transparent Liquid

Key Parameter

Peptide Content ≥ 99% (Powder) / 1000ppm (Liquid)

Solubility

Highly Water-Soluble

Direct Factory Supply

Source directly from manufacturer. Zero middlemen margin, guaranteed bulk competitive pricing.

Flexible OEM/ODM

Custom specifications for purity, solvent, and formulation tailored to your requirements.

Stable Supply Chain

Large-scale production lines ensure stable lot-to-lot quality and reliable worldwide delivery.

Strict QA & Certs

ISO, Halal, Kosher, and SC certified manufacturing with batch COA test reports.

High-Purity Acetyl Hexapeptide-8 (≥ 98.0%): Farnesol-Free Neuropeptide Active

Formulating elite anti-aging serums and non-invasive wrinkle-smoothing lines requires advanced neuropeptides that attenuate dynamic expression lines without introducing contact sensitization, solvent residues, or formulation instability. Manufactured by Shaanxi Huatai Bio-Fine Chemicals Co. via precision solid-phase peptide synthesis, our Cosmetic-Grade Acetyl Hexapeptide-8 is meticulously refined to maintain a strict 100% farnesol-free profile.

By competing with SNAP-25 to destabilize the SNARE complex and modulate neurotransmitter release, this high-purity active safely reduces repetitive muscle contractions and softens deep expression lines for hyper-reactive skin architectures.

Clinical Efficacy & Pharmacological Performance (MoA)

  • Expression Line Reduction: Clinically documented to visibly reduce wrinkle depth by up to 30% after a 30-day continuous application protocol.

  • Rapid Smoothing Action: Demonstrates a significant decrease in the appearance of fine lines and crow’s feet within just 15 days of consistent use.

  • Sensitivity Downregulation: Pharmacological evaluations confirm a 40% reduction in key epidermal sensitivity markers within 48 hours, establishing an impeccable safety profile for compromised barriers.

Technical Data & Physical Specifications Engineered to eliminate manufacturing friction for OEM/ODM innovators, this high-purity peptide dissolves cleanly into aqueous systems, yielding an absolute crystal-clear, water-white, and odorless profile.

ParameterSpecification & Standard
INCI NameAcetyl Hexapeptide-8
CAS Number616204-22-9
Farnesol ContentN.D. (Limit of Detection < 1ppm)
Purity Assay (HPLC)≥ 98.0% (Guaranteed high biological potency)
Acetate Content< 15%
AppearanceCrystal-clear, water-white liquid / High-purity powder
Odor ProfileOdorless (Scent-neutral)
pH Range StabilityExceptionally stable between 3.0 – 6.0
Heavy Metals (Pb, As, Hg, Cd)< 10 ppm

Formulation Directives & Synergistic Matrices Water-soluble and optimized for modern cold-process manufacturing. Incorporate directly into the aqueous phase during the final cooling stage below 40°C to preserve peak peptide bioactivity.

Target ApplicationRecommended DosageCompanion Actives & Mechanistic Synergy
Non-Invasive Lifting3.0% – 10.0% (1000ppm solution)Peptide + Allantoin: Combines dynamic muscle-relaxing power with water-soluble micro-trauma healing to rapidly soothe hyper-reactive skin during intensive treatments.
SOS Barrier Smoothing2.0% – 5.0%Peptide + Panthenol: Panthenol floods the stratum corneum with deep hydration, creating a non-reactive environment for the neuropeptide to inhibit neurotransmitter release without tightness.
Structural Anti-Aging5.0% – 10.0%Peptide + Ceramide NP: Reduces muscle tension and smooths expression lines from within while Ceramide NP physically reconstructs the depleted surface lipid cement.

Procurement, Compliance & Supply Chain Shaanxi Huatai adheres strictly to global cosmetic safety benchmarks. By ensuring absolute batch-to-batch consistency and complete regulatory transparency, we streamline compliance filings for global personal care brands.

Procurement ParameterFulfillment Details
Minimum Order Quantity (MOQ)Flexible configurations (Highly accessible for laboratory R&D trials and pilot batch runs)
Global CertificationsISO, COSMOS Approved standards, HALAL
Quality DocumentationBatch-specific Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), Technical Data Sheet (TDS), and HPLC purity testing reports provided with all shipments.
Logistics & DeliveryFactory-direct global shipping via air freight ensures rapid delivery for uninterrupted production schedules.

Accelerate Your R&D Pipeline Stop compromising on formula stability, invasive side effects, and ingredient-induced skin irritation. Secure your supply chain with our factory-direct, highly purified neuropeptide actives and empower your next formulation with medical-grade wrinkle-smoothing efficacy.

  • Request a Free R&D Sample for immediate formulation compatibility and sensory evaluation.

  • Download the Full Technical Dossier (COA, MSDS, TDS, and Safety Reports).

  • Access Customized Bulk Wholesale Pricing.

Contact our technical sales team directly to initiate your procurement request and secure factory-direct allocations today.

Empower Your Skin Science: Develop Next-Generation Formulations with Our Premium Active Ingredients.

Huatai Bio provides a comprehensive portfolio of high-efficacy cosmetic active ingredients, empowering global brands to create next-generation skincare formulations for high-end skincare formulation needs.

Comprehensive Solutions & Innovation: Our categories cover the full spectrum of market requirements: Anti-aging & Firming, Oil-Control & Anti-acne, Anti-inflammatory & Soothing,Antioxidant Defense, Brightening,and Hydration & Barrier Repair.We offer both established classics and cutting-edge actives.

Driven by a passion for scientific excellence, our state-of-the-art R&D laboratory is dedicated to exploring the frontier of bio-active molecules. Beyond supplying ingredients, we offer end-to-end formulation consultancy and customized solution development. Our team of expert chemists works closely with your brand to overcome complex stability issues and sensory challenges, ensuring your final product stands out in a competitive global market.

Uncompromising Quality & Credibility:We ensure every batch of our Active skincare ingredients meets rigorous quality standards, including COSMOS, ISO 9001/22000, and HALAL Certification. This commitment, backed by a complete Technical Dossier, offers clinically-backed solutions and guaranteed compliance for every formulation challenge.

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