Dihydroavenanthramide D
The Potent Natural Alternative for Intensive Anti-Itch and Sensitivity Relief
Dihydroavenanthramide D is a nature-inspired, high-performance cosmetic grade active synthesized to mimic the powerful soothing alkaloids found in oats. It is widely recognized as a “Steroid-Free” solution for rapidly suppressing itchiness, redness, and allergic responses, providing a safe and effective treatment for compromised and hyper-reactive skin barriers.
| CAS No. | 697235-49-7 |
|---|---|
| Source | High-Purity Biomimetic Synthesis |
| Appearance Color | Colorless to Light Yellow Transparent Liquid |
| Key Parameter | Inhibition of Histamine Release / High Purity |
| Solubility | Water-Soluble (Propylene Glycol base) |
Direct Factory Supply
Source directly from manufacturer. Zero middlemen margin, guaranteed bulk competitive pricing.
Flexible OEM/ODM
Custom specifications for purity, solvent, and formulation tailored to your requirements.
Stable Supply Chain
Large-scale production lines ensure stable lot-to-lot quality and reliable worldwide delivery.
Strict QA & Certs
ISO, Halal, Kosher, and SC certified manufacturing with batch COA test reports.
Dihydroavenanthramide D (5% Solution): Steroid-Free Neuro-Calming Active for Sensitive Skin
Formulating for hyper-reactive, eczema-prone, and post-procedure skin requires intercepting neurogenic inflammation without relying on corticosteroids. Engineered by Shaanxi Huatai Bio-Fine Chemicals Co., this premium Dihydroavenanthramide D is a high-purity, farnesol-free synthetic analog of active oat compounds. It directly targets mast cells to inhibit histamine degranulation while suppressing pro-inflammatory cytokines (IL-8 and TNF-α). This mechanism provides immediate relief from pruritus (itching), erythema (redness), and stinging sensations, establishing a flawless safety profile for infant care and clinical-grade recovery serums.
Clinical Efficacy & Mechanism of Action (MoA)
Histamine Inhibition: Demonstrates 30x higher inhibitory potency against histamine release compared to conventional natural oat extracts.
Erythema Reduction: Clinically validated to decrease UV-induced skin redness by 50% within a 24-hour observation window.
Sensitivity Downregulation: Reduces critical epidermal irritation markers by 40% within 48 hours of application, breaking the chronic itch-scratch cycle.
Core Technical Data & Physical Specifications To eliminate manufacturing friction for OEM/ODM innovators, this active is pre-solubilized into a highly stable liquid matrix, ensuring zero formula discoloration and absolute optical clarity in aqueous systems.
| Parameter | Specification & Standard |
| Active Component | Hydroxyphenyl Propamidobenzoic Acid (Dihydroavenanthramide D) |
| Active Concentration | Standardized 5.0% Solution |
| Farnesol & Steroid Content | N.D. (Not Detected / 100% Free) |
| Appearance | Crystal-clear, water-white liquid |
| Odor Profile | Odorless (Scent-neutral) |
| Solubility | Water-soluble (Readily incorporates into the aqueous phase) |
| pH Stability Range | 3.5 – 7.0 |
| Heavy Metals (Pb, As, Hg, Cd) | < 10 ppm |
Formulation Directives & Synergistic Matrices This active functions as a supreme biological neuro-calmer. It can be added to the aqueous phase or during the final cool-down stage (<45°C) of emulsion processes.
| Companion Active | Mechanistic Synergy | Target Formulation |
| Dihydroavenanthramide D + Allantoin | Rapid Pruritus Relief: Merges histamine suppression with water-soluble cellular micro-trauma healing. | Anti-itch lotions, Scalp care, Post-laser recovery gels |
| Dihydroavenanthramide D + Panthenol | Hydrating Erythema Control: Halts inflammatory triggers while flooding the stratum corneum with targeted cellular energy. | SOS Barrier Rescue serums, After-sun treatments |
| Dihydroavenanthramide D + Ceramide NP | Structural Anti-Allergy Complex: Silences internal nerve ending discomfort while physically rebuilding the depleted surface lipid cement. | Eczema-prone defense creams, Premium infant care |
Procurement, Compliance & Supply Chain Shaanxi Huatai strictly enforces global cosmetic safety benchmarks, ensuring the absence of pharmaceutical contaminants for absolute regulatory confidence.
| Procurement Parameter | Fulfillment Details |
| Minimum Order Quantity (MOQ) | 1 kg (Friendly for R&D trials and pilot batch productions) |
| Recommended Dosage | 1.0% – 5.0% (Daily Care) / Up to 10.0% (Intensive SOS Treatments) |
| Global Certifications | ISO, COSMOS, HALAL |
| Quality Documentation | Batch-specific COA, MSDS, TDS, and purity testing reports provided with every shipment. |
| Logistics & Lead Time | Factory-direct global shipping via FedEx/DHL air freight, guaranteeing rapid delivery without middleman delays. |
Accelerate Your R&D Pipeline
Upgrade your formulations with the industry standard in non-sensitizing, steroidal-free neuro-calming technology. Secure your supply chain directly with the manufacturer to ensure batch-to-batch consistency and competitive factory pricing.
Request a Free R&D Sample for immediate formulation compatibility testing.
Download the Full Technical Dossier (COA, MSDS, TDS).
Access Customized Bulk Wholesale Pricing.
Contact our technical sales team directly to initiate your procurement request and secure factory allocations.
Huatai Bio provides a comprehensive portfolio of high-efficacy cosmetic active ingredients, empowering global brands to create next-generation skincare formulations for high-end skincare formulation needs.
Comprehensive Solutions & Innovation: Our categories cover the full spectrum of market requirements: Anti-aging & Firming, Oil-Control & Anti-acne, Anti-inflammatory & Soothing,Antioxidant Defense, Brightening,and Hydration & Barrier Repair.We offer both established classics and cutting-edge actives.
Driven by a passion for scientific excellence, our state-of-the-art R&D laboratory is dedicated to exploring the frontier of bio-active molecules. Beyond supplying ingredients, we offer end-to-end formulation consultancy and customized solution development. Our team of expert chemists works closely with your brand to overcome complex stability issues and sensory challenges, ensuring your final product stands out in a competitive global market.
Uncompromising Quality & Credibility:We ensure every batch of our Active skincare ingredients meets rigorous quality standards, including COSMOS, ISO 9001/22000, and HALAL Certification. This commitment, backed by a complete Technical Dossier, offers clinically-backed solutions and guaranteed compliance for every formulation challenge.
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