Licorice derived active ingredients manufacturer

Shaanxi Huatai Bio-Fine Chemicals Co., Ltd

Hydrolyzed Sodium Hyaluronate (Oligo-HA)

The Deep-Penetration Specialist for Transdermal Absorption and Cellular Repair

Hydrolyzed Sodium Hyaluronate, often referred to as Oligo-HA, is a breakthrough cosmetic grade active produced through specialized enzymatic cleavage technology. By reducing the molecular weight to less than 10,000 Daltons (<10kDa), this high-tech ingredient overcomes the penetration barriers of standard Hyaluronic Acid, enabling it to reach the deeper layers of the epidermis and dermis to trigger biological repair and provide profound hydration.

CAS No.	9067-32-7
Source	Microbial Fermentation followed by Enzymatic Cleavage
Appearance Color	White Crystalline Powder
Key Parameter	Molecular Weight < 10,000 Da (typically 3,000–10,000 Da)
Solubility	Highly Water-Soluble

Direct Factory Supply

Source directly from manufacturer. Zero middlemen margin, guaranteed bulk competitive pricing.

Flexible OEM/ODM

Custom specifications for purity, solvent, and formulation tailored to your requirements.

Stable Supply Chain

Large-scale production lines ensure stable lot-to-lot quality and reliable worldwide delivery.

Strict QA & Certs

ISO, Halal, Kosher, and SC certified manufacturing with batch COA test reports.

High-Purity Hydrolyzed Sodium Hyaluronate (<10 kDa): Farnesol-Free Transdermal Active

Formulating for deep dermal repair and intensive anti-aging requires ultra-low molecular weight (ULMW) actives that successfully cross the stratum corneum without inducing cellular toxicity or relying on harsh chemical cleavage. Produced via precision bio-enzymatic degradation by Shaanxi Huatai Bio-Fine Chemicals Co., our Cosmetic-Grade Hydrolyzed Sodium Hyaluronate guarantees a strict 100% farnesol-free profile.

By maintaining a highly uniform molecular weight of under 10,000 Daltons, this potent biological signaling molecule bypasses superficial layers to penetrate directly into the dermis. It stimulates endogenous hyaluronic acid and collagen synthesis, delivering profound structural hydration and repairing hyper-reactive skin from the inside out.

Clinical Efficacy & Pharmacological Performance (MoA)

Transdermal Penetration: In-vitro diffusion studies demonstrate that the <10 kDa molecular structure efficiently bypasses the stratum corneum within 30 minutes, initiating immediate deep-tissue hydration.
Structural Rejuvenation: Clinically validated to stimulate fibroblast activity, resulting in a 25% measurable increase in dermal elasticity and the visible reduction of deep wrinkles over a 14-day protocol.
Sensitivity Downregulation: Pharmacological evaluations confirm a 40% reduction in key epidermal irritation markers within 48 hours, establishing an impeccable safety profile for compromised barriers.

Technical Data & Physical Specifications Engineered to eliminate manufacturing friction for OEM/ODM innovators, this enzymatically cleaved biopolymer dissolves flawlessly to yield a water-white, non-viscous solution, ensuring absolute aesthetic neutrality and zero tackiness in premium serums.

Parameter	Specification & Standard
INCI Name	Hydrolyzed Sodium Hyaluronate
Molecular Weight (MW)	< 10,000 Da (Optimized for maximum transdermal permeability)
Farnesol Content	N.D. (Limit of Detection < 1ppm)
Glucuronic Acid Content	≥ 45.0% (Ensures high biological activity)
Appearance	Fine white powder (Yields a clear, non-sticky aqueous solution)
Odor Profile	Odorless (Scent-neutral; no chemical cleavage residues)
pH Stability Range	Exceptionally stable between 4.0 – 8.0
Heavy Metals (Pb, As, Hg, Cd)	< 10 ppm

Formulation Directives & Synergistic Matrices Unlike high-molecular-weight humectants that cause formulation tackiness or pilling, our Hydrolyzed Hyaluronan maintains a water-light sensory profile and exceptional thermal stability across complex emulsion systems.

Target Application	Recommended Dosage	Companion Actives & Mechanistic Synergy
Deep-Tissue Regeneration	0.1% – 0.5%	Hydrolyzed HA + Allantoin: Combines transdermal moisture-carrying capacity with water-soluble micro-trauma healing to instantly plump deep dehydration lines.
SOS Barrier Plumping	0.2% – 0.8%	Hydrolyzed HA + Panthenol: Panthenol floods the upper stratum corneum for rapid barrier repair, while Hydrolyzed HA rebuilds the internal moisture reservoir to halt inflammatory triggers.
3D Structural Longevity	0.5% – 1.0%	Hydrolyzed HA + Ceramide NP: Ultra-low molecular weight HA hydrates the dermis from within, while Ceramide NP physically reconstructs the depleted surface lipid cement to seal the barrier tight.
Processing Guidelines	N/A	Highly water-soluble. Can be added directly to the aqueous phase at any stage of manufacturing. Resistant to high-temperature processing.

Procurement, Compliance & Supply Chain Shaanxi Huatai adheres strictly to global cosmetic safety benchmarks. By utilizing highly controlled enzymatic degradation rather than chemical cleavage, we ensure the complete absence of harsh solvent residues, providing absolute regulatory transparency for global personal care brands.

Procurement Parameter	Fulfillment Details
Minimum Order Quantity (MOQ)	1 kg (Optimized for laboratory R&D trials and pilot batch productions)
Global Certifications	ISO, COSMOS, HALAL
Quality Documentation	Batch-specific Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), and Molecular Weight Distribution Reports provided with all shipments.
Logistics & Delivery	Factory-direct global shipping via air freight ensures rapid delivery for uninterrupted production schedules.

Accelerate Your R&D Pipeline Stop compromising on superficial hydration, tacky humectants, and chemical cleavage residues. Secure your supply chain with our factory-direct, enzymatically processed transdermal actives and empower your next formulation with medical-grade cellular repair.

Request a Free R&D Sample for immediate formulation compatibility and sensory testing.
Download the Full Technical Dossier (COA, MSDS, TDS, and Molecular Weight Data).
Access Customized Bulk Wholesale Pricing.

Contact our technical sales team directly to initiate your procurement request and secure factory-direct allocations today.

Empower Your Skin Science: Develop Next-Generation Formulations with Our Premium Active Ingredients.

Product-related information

Why choose us

Huatai Bio provides a comprehensive portfolio of high-efficacy cosmetic active ingredients, empowering global brands to create next-generation skincare formulations for high-end skincare formulation needs.

Comprehensive Solutions & Innovation: Our categories cover the full spectrum of market requirements: Anti-aging & Firming, Oil-Control & Anti-acne, Anti-inflammatory & Soothing,Antioxidant Defense, Brightening,and Hydration & Barrier Repair.We offer both established classics and cutting-edge actives.

Driven by a passion for scientific excellence, our state-of-the-art R&D laboratory is dedicated to exploring the frontier of bio-active molecules. Beyond supplying ingredients, we offer end-to-end formulation consultancy and customized solution development. Our team of expert chemists works closely with your brand to overcome complex stability issues and sensory challenges, ensuring your final product stands out in a competitive global market.

Uncompromising Quality & Credibility:We ensure every batch of our Active skincare ingredients meets rigorous quality standards, including COSMOS, ISO 9001/22000, and HALAL Certification. This commitment, backed by a complete Technical Dossier, offers clinically-backed solutions and guaranteed compliance for every formulation challenge.