Licorice derived active ingredients manufacturer

Shaanxi Huatai Bio-Fine Chemicals Co., Ltd

Liquiritigenin

The Ultra-Fast Neuro-Soothing Specialist for Stinging and Redness Relief

Liquiritigenin is a high-purity flavonoid aglycone derived from Licorice (Glycyrrhiza glabra). It is a premium cosmetic grade active specifically engineered to address “Neurogenic Inflammation”—the immediate stinging and burning sensations often felt by sensitive skin. By targeting the sensory nerve response, it provides a “lightning-fast” calming effect and visibly reduces transient redness.

CAS No.	578-86-9
Source	High-Purity Licorice Root Extraction
Appearance Color	White to Off-white Crystalline Powder
Key Parameter	Purity ≥ 98.0% / Fast-Acting Sensory Relief
Solubility	Soluble in Ethanol and Glycols; Partially Water-Soluble

Direct Factory Supply

Source directly from manufacturer. Zero middlemen margin, guaranteed bulk competitive pricing.

Flexible OEM/ODM

Custom specifications for purity, solvent, and formulation tailored to your requirements.

Stable Supply Chain

Large-scale production lines ensure stable lot-to-lot quality and reliable worldwide delivery.

Strict QA & Certs

ISO, Halal, Kosher, and SC certified manufacturing with batch COA test reports.

High-Purity Liquiritigenin (≥ 98.0%): Farnesol-Free TRPV1 Modulator & Tyrosinase Inhibitor

Formulating for hyper-reactive and compromised skin requires active agents that can instantly dampen neurogenic inflammation while delivering visible complexion improvements without inducing secondary irritation. Extracted and highly purified by Shaanxi Huatai Bio-Fine Chemicals Co., this premium natural flavonoid aglycone (Liquiritigenin) provides a sophisticated dual-pathway solution. It acts as a rapid TRPV1 receptor antagonist to “switch off” stinging and erythema, while simultaneously serving as a potent tyrosinase inhibitor for gentle brightening. Rigorously processed to be completely farnesol-free and devoid of glycyrrhizic acid residues, it establishes an impeccable safety profile for clinical-grade SOS serums.

Clinical Efficacy & Mechanism of Action (MoA)

Neurogenic Calming (TRPV1 Inhibition): Clinically validated to decrease perceived stinging, burning, and heat sensations by 60% within a rapid 3-minute window, halting the localized inflammatory cascade at the receptor level.
Melanogenesis Regulation: Effectively downregulates tyrosinase activity, offering powerful antioxidant protection and dark spot correction specifically tailored for sensitive skin types that cannot tolerate harsh exfoliating acids.

Technical Data & Physical Specifications Unlike crude licorice extracts that severely darken formulations, our highly refined Liquiritigenin guarantees water-white clarity when properly solubilized, ensuring absolute aesthetic neutrality for your high-end emulsions.

Parameter	Specification & Standard
INCI Name	Glycyrrhiza Glabra (Licorice) Root Extract / Liquiritigenin
CAS Number	2188-67-2
Farnesol Content	N.D. (Limit of Detection < 1ppm)
Purity Profile (HPLC)	≥ 98.0% (Zero residual glycyrrhizic acid)
Appearance	Fine, highly refined off-white powder
Odor Profile	Odorless (Scent-neutral)
Heavy Metals (Pb, As, Hg, Cd)	< 10 ppm

Formulation Directives & Synergistic Matrices This active acts as a supreme biological neuro-calmer, eliminating manufacturing friction for OEM/ODM innovators looking to upgrade their “Clean Beauty” and sensitive skin lines.

Formulation Parameter	Application Directives & Companion Synergies
Standard Dosage	0.05% – 0.2% (Daily Brightening/Care) / Up to 0.5% (Intensive SOS Rescue Serums)
Solubility & Processing	Pre-dissolve completely in cosmetic glycols (such as Propanediol or Butylene Glycol) before adding to the formulation. (Insoluble in pure water).
pH Stability Range	Exceptionally stable between 4.0 – 7.0
Liquiritigenin + Allantoin	Rapid Stinging Relief: Merges the TRPV1 neural inhibition of Liquiritigenin with the water-soluble cellular micro-trauma healing of Allantoin.
Liquiritigenin + Panthenol	Non-Reactive Hydration: Panthenol floods the barrier with deep hydration, creating an optimal environment for Liquiritigenin to reduce inflammatory vasodilation.
Liquiritigenin + Ceramide NP	Comprehensive Defense: Halts acute sensory reactivity from within while Ceramide NP physically rebuilds the depleted surface lipid cement.

Procurement, Compliance & Supply Chain Shaanxi Huatai strictly enforces global cosmetic safety benchmarks. Our state-of-the-art licorice extraction facility ensures consistent batch-to-batch stability and full regulatory transparency.

Procurement Parameter	Fulfillment Details
Minimum Order Quantity (MOQ)	1 kg (Highly accessible for R&D trials and pilot batch productions)
Global Certifications	ISO, COSMOS, HALAL
Quality Documentation	Batch-specific Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), and HPLC purity testing reports provided with all shipments.
Logistics & Lead Time	3-5 working days globally for in-stock inventory via factory-direct air freight.

Accelerate Your R&D Pipeline

Stop compromising on crude extract discoloration and ingredient stability. Secure your supply chain with our factory-direct, highly purified botanical derivatives and elevate your formulations with medical-grade soothing efficacy.

Request a Free R&D Sample for immediate formulation compatibility and stability testing.
Download the Full Technical Dossier (COA, MSDS, TDS, HPLC Reports).
Access Customized Bulk Wholesale Pricing.

Contact our technical sales team directly to initiate your procurement request and secure factory-direct allocations today.

Empower Your Skin Science: Develop Next-Generation Formulations with Our Premium Active Ingredients.

Product-related information

Why choose us

Huatai Bio provides a comprehensive portfolio of high-efficacy cosmetic active ingredients, empowering global brands to create next-generation skincare formulations for high-end skincare formulation needs.

Comprehensive Solutions & Innovation: Our categories cover the full spectrum of market requirements: Anti-aging & Firming, Oil-Control & Anti-acne, Anti-inflammatory & Soothing,Antioxidant Defense, Brightening,and Hydration & Barrier Repair.We offer both established classics and cutting-edge actives.

Driven by a passion for scientific excellence, our state-of-the-art R&D laboratory is dedicated to exploring the frontier of bio-active molecules. Beyond supplying ingredients, we offer end-to-end formulation consultancy and customized solution development. Our team of expert chemists works closely with your brand to overcome complex stability issues and sensory challenges, ensuring your final product stands out in a competitive global market.

Uncompromising Quality & Credibility:We ensure every batch of our Active skincare ingredients meets rigorous quality standards, including COSMOS, ISO 9001/22000, and HALAL Certification. This commitment, backed by a complete Technical Dossier, offers clinically-backed solutions and guaranteed compliance for every formulation challenge.