The Essential Barrier Fortifier for Cellular Growth and Intensive Hydration
Panthenol, the stable precursor to Vitamin B5 (Pantothenic Acid), is a foundational cosmetic grade active celebrated for its multi-functional efficacy. It acts as both a powerful humectant and a biological catalyst, promoting epithelial cell proliferation and accelerating the skin’s natural repair process to create a visibly stronger and more hydrated barrier.
| CAS No. | 81-13-0 (D-Panthenol) / 16485-10-2 (DL-Panthenol) |
|---|---|
| Source | High-Purity Cosmetic Synthesis |
| Appearance Color | Colorless to Pale Yellow Viscous Liquid (D) / White Powder (DL) |
| Key Parameter | Purity ≥ 98.0% / High Hygroscopicity |
| Solubility | Highly Water-Soluble / Soluble in Alcohol |
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Formulating restorative hydration for compromised skin barriers requires highly biocompatible actives that fuel cellular energy without inducing contact dermatitis. Engineered by Shaanxi Huatai Bio-Fine Chemicals Co., our Cosmetic-Grade D-Panthenol is rigorously purified to maintain a strict 100% farnesol-free profile. Upon penetrating the dermis, this bioactive molecule rapidly converts into Pantothenic Acid (Vitamin B5), stimulating fibroblast proliferation and lipid synthesis. It provides an immediate structural defense mechanism, mitigating the inflammatory cascade while delivering profound, non-tacky hydration to hyper-reactive skin.
Clinical Efficacy & Mechanism of Action (MoA)
Barrier Restoration (TEWL Reduction): Clinically documented to decrease Transepidermal Water Loss by 35%, actively rebuilding the epidermal moisture shield.
Tissue Regeneration: Accelerates the physiological repair of damaged stratum corneum, demonstrating visible structural recovery within a 7-day application cycle.
Sensitivity Downregulation: Pharmacological evaluations confirm a 40% reduction in key epidermal irritation markers within 48 hours, eliminating the sensitization risks associated with crude humectants.
Active Component Selection Guide & Specifications To eliminate manufacturing friction and support diverse emulsion systems, we supply the biologically active dextrorotatory (D-form) isomer in two specialized cosmetic grades, avoiding the lower-efficacy synthetic DL-mixtures.
| Parameter | D-Panthenol 99% (Powder) | D-Panthenol 75W (Liquid) |
|---|---|---|
| INCI Name | Panthenol | Panthenol (and) Water |
| CAS Number | 81-13-0 | 81-13-0 ; 7732-18-5 |
| Active Concentration | ≥ 99.0% | 75.0% Aqueous Solution |
| Farnesol Content | N.D. (Limit of Detection < 1ppm) | N.D. (Limit of Detection < 1ppm) |
| Appearance | White crystalline powder | Clear, highly viscous water-white liquid |
| Specific Rotation | +29.0° to +31.5° | +29.0° to +31.5° (on dry basis) |
| Solubility | Highly water-soluble | Fully miscible in water |
| Heavy Metals (Pb, As) | < 10 ppm | < 10 ppm |
Formulation Directives & Synergistic Matrices D-Panthenol exhibits exceptional thermal and pH stability, integrating seamlessly into both hot and cold-process manufacturing without compromising the aesthetic or olfactory profile of the final formulation.
| Target Application | Recommended Dosage | Companion Actives & Mechanistic Synergy |
|---|---|---|
| Daily Barrier Hydration | 1.0% – 5.0% | Panthenol + Ceramide NP: Panthenol floods the lower epidermis with targeted cellular energy, while Ceramide NP physically reconstructs the depleted surface lipid cement for absolute structural defense. |
| Post-Procedure Recovery | 5.0% – 10.0% | Panthenol + Allantoin: Combines the deep-penetrating fibroblast stimulation of Provitamin B5 with the water-soluble cellular micro-trauma healing of Allantoin to instantly clear erythema. |
| Processing Guidelines | N/A | Exceptionally stable between pH 4.0 – 7.5. For emulsions, incorporation into the aqueous phase below 40°C is recommended to preserve maximum bioactivity. |
Procurement, Compliance & Supply Chain Shaanxi Huatai adheres strictly to global cosmetic safety benchmarks. By isolating the pure INCI-standardized active molecule, we ensure absolute regulatory transparency and seamless supply chain integration for global personal care innovators.
| Procurement Parameter | Fulfillment Details |
|---|---|
| Minimum Order Quantity (MOQ) | 1 kg (Optimized for laboratory R&D trials and pilot batch productions) |
| Global Certifications | ISO, COSMOS, HALAL |
| Quality Documentation | Batch-specific Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), and purity testing reports provided with all shipments. |
| Logistics & Processing | Factory-direct global shipping via air freight ensures rapid delivery for uninterrupted production schedules. |
Accelerate Your R&D Pipeline
Eliminate formula instability, sticky residues, and ingredient-induced irritation. Secure your supply chain with our factory-direct, highly purified Provitamin B5 and empower your next formulation with medical-grade barrier repair.
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Huatai Bio provides a comprehensive portfolio of high-efficacy cosmetic active ingredients, empowering global brands to create next-generation skincare formulations for high-end skincare formulation needs.
Comprehensive Solutions & Innovation: Our categories cover the full spectrum of market requirements: Anti-aging & Firming, Oil-Control & Anti-acne, Anti-inflammatory & Soothing,Antioxidant Defense, Brightening,and Hydration & Barrier Repair.We offer both established classics and cutting-edge actives.
Driven by a passion for scientific excellence, our state-of-the-art R&D laboratory is dedicated to exploring the frontier of bio-active molecules. Beyond supplying ingredients, we offer end-to-end formulation consultancy and customized solution development. Our team of expert chemists works closely with your brand to overcome complex stability issues and sensory challenges, ensuring your final product stands out in a competitive global market.
Uncompromising Quality & Credibility:We ensure every batch of our Active skincare ingredients meets rigorous quality standards, including COSMOS, ISO 9001/22000, and HALAL Certification. This commitment, backed by a complete Technical Dossier, offers clinically-backed solutions and guaranteed compliance for every formulation challenge.
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