The Water-Soluble Azelaic Acid Derivative for Dual-Action Sebum Control and Brightening
Potassium Azeloyl Diglycinate (PAD) is a high-performance cosmetic-grade derivative of Azelaic Acid. Known for its exceptional water solubility and skin tolerance, it provides a sophisticated solution for managing oily, acne-prone skin while simultaneously promoting a brighter, more even skin tone. Unlike pure Azelaic Acid, PAD offers significant moisturizing benefits and is effortlessly incorporated into diverse skincare formulations.
| CAS No. | 473728-74-0 |
|---|---|
| Source | High-Purity Cosmetic Synthesis |
| Appearance Color | Colorless to Light Yellow Clear Liquid |
| Key Parameter | Active Content: 28.0% – 32.0% |
| Solubility | Highly Water-Soluble |
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Formulating advanced blemish-control and oil-balancing systems requires water-soluble azelaic acid derivatives that suppress sebum production without triggering the crystallization, extreme dryness, or surface stinging typical of crude acids. Manufactured by Shaanxi Huatai Bio-Fine Chemicals Co., our Cosmetic-Grade Potassium Azeloyl Diglycinate (PAD) is meticulously refined to maintain a strict 100% farnesol-free profile.
By chemically conjugating azelaic acid with glycine, this high-purity bio-derivative competitively inhibits 5$\alpha$-reductase activity while simultaneously delivering deep hydration, establishing a clinical-grade solution for oily, acne-prone, and rosacea-sensitive skin architectures.
Clinical Efficacy & Pharmacological Performance (MoA)
Sebum Normalization: Clinically documented to decrease skin sebum levels by an average of over 25% within a 3-week continuous application protocol.
Dermal Hydration: Significantly increases moisture retention and epidermal hydration, offsetting the dehydration commonly linked to traditional acne treatments.
Sensitivity Downregulation: Pharmacological evaluations confirm a 40% reduction in key epidermal irritation markers within 48 hours, establishing an impeccable safety profile for hyper-reactive barriers.
Technical Data & Physical Specifications Engineered to completely eliminate the solubility and precipitation bottlenecks associated with pure azelaic acid, our standardized liquid complex dissolves seamlessly into aqueous systems, yielding an absolute water-white, odorless profile.
| Parameter | Specification & Standard |
|---|---|
| INCI Name | Potassium Azeloyl Diglycinate |
| Active Content | 30.0% ± 2.0% Aqueous Solution |
| Farnesol Content | N.D. (Limit of Detection < 1ppm) |
| Appearance | Crystal-clear, water-white liquid |
| Odor Profile | Odorless (Scent-neutral) |
| pH (Direct Measurement) | 6.5 – 8.5 (Suggested final product pH: 6.0 – 7.5) |
| pH Stability Range | Exceptionally stable between 5.0 – 9.0 |
| Heavy Metals (Pb, As, Hg, Cd) | < 10 ppm |
Formulation Directives & Synergistic Matrices Highly water-soluble and designed for effortless integration. Incorporate directly during the cold-process phase or below 40°C in the final stage of emulsification to preserve peak bioactivity.
| Target Application | Recommended Dosage | Companion Actives & Mechanistic Synergy |
|---|---|---|
| Blemish & Sebum Control | 2.0% – 8.0% | PAD + Allantoin: Combines 5$\alpha$-reductase inhibition with water-soluble cellular micro-trauma healing to rapidly clear comedones and soothe irritated skin. |
| SOS Oily-Sensitive Relief | 5.0% – 10.0% | PAD + Panthenol: Panthenol floods the stratum corneum with deep hydration, creating a non-reactive environment that synergizes with the glycine component to regulate oil without flakiness. |
| Rosacea-Safe Brightening | 3.0% – 8.0% | PAD + Ceramide NP: Controls sebaceous gland activity from within while Ceramide NP physically reconstructs the depleted surface lipid cement for absolute barrier protection. |
Procurement, Compliance & Supply Chain Shaanxi Huatai adheres strictly to global cosmetic safety benchmarks. By ensuring absolute batch-to-batch consistency and complete regulatory transparency, we streamline compliance filings for global personal care brands.
| Procurement Parameter | Fulfillment Details |
|---|---|
| Minimum Order Quantity (MOQ) | 1 kg (Optimized for laboratory R&D trials and pilot batch productions) |
| Global Certifications | ISO 9001, ISO 22000, COSMOS Approved standards, HALAL |
| Quality Documentation | Batch-specific Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), Technical Data Sheet (TDS), and purity testing reports provided with all shipments. |
| Logistics & Delivery | Factory-direct global shipping via air freight ensures rapid delivery for uninterrupted production schedules. |
Accelerate Your R&D Pipeline Stop compromising on formula stability, insoluble acid crystallization, and ingredient-induced skin irritation. Secure your supply chain with our factory-direct, highly stable sebum-regulating actives and empower your next formulation with medical-grade oil control.
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Huatai Bio provides a comprehensive portfolio of high-efficacy cosmetic active ingredients, empowering global brands to create next-generation skincare formulations for high-end skincare formulation needs.
Comprehensive Solutions & Innovation: Our categories cover the full spectrum of market requirements: Anti-aging & Firming, Oil-Control & Anti-acne, Anti-inflammatory & Soothing,Antioxidant Defense, Brightening,and Hydration & Barrier Repair.We offer both established classics and cutting-edge actives.
Driven by a passion for scientific excellence, our state-of-the-art R&D laboratory is dedicated to exploring the frontier of bio-active molecules. Beyond supplying ingredients, we offer end-to-end formulation consultancy and customized solution development. Our team of expert chemists works closely with your brand to overcome complex stability issues and sensory challenges, ensuring your final product stands out in a competitive global market.
Uncompromising Quality & Credibility:We ensure every batch of our Active skincare ingredients meets rigorous quality standards, including COSMOS, ISO 9001/22000, and HALAL Certification. This commitment, backed by a complete Technical Dossier, offers clinically-backed solutions and guaranteed compliance for every formulation challenge.
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